MAPK15 - Mitogen-activated protein kinase 15 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MAPK15 »  Mitogen-activated protein kinase 15   [ EC 2.7.11.24 ]  (MAPK 15)
 
Protein also known as:  Extracellular signal-regulated kinase 8 (ERK-8).
Gene name:  MAPK15
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 3
GENE REF ISO

Function

 show evidences
Overview 
In vitro, phosphorylates MBP.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase activitydefinition[GO:0004707]  
1
  • IDAUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
1
  • NASUniProtKB
GO biological process 
MAPK cascadedefinition[GO:0000165]  
1
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Negative regulation of DNA replicationdefinition[GO:0008156] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of protein ubiquitinationdefinition[GO:0031398] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK15
GenomeRNAi: 225689
PRO: PR:Q8TD08
Chemistry
GuidetoPHARMACOLOGY: 2090