MAPK15 - Mitogen-activated protein kinase 15 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
MAPK15 »  Mitogen-activated protein kinase 15   [ EC 2.7.11.24 ]  (MAPK 15)
 
Protein also known as:  Extracellular signal-regulated kinase 8 (ERK-8).
Gene name:  MAPK15
Entry whose protein(s) existence is based on evidence at protein level
extend overview
2 22 3
GENE REF ISO

Function

 show evidences
Overview 
In vitro, phosphorylates MBP.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
MAP kinase activitydefinition[GO:0004707]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
GO biological process 
MAPK cascadedefinition[GO:0000165]  
3
  • GOC
  • InterPro 2 GO
  • EC 2 GO
Positive regulation of telomerase activitydefinition[GO:0051973]  
2
  • BHF-UCL
Positive regulation of telomere cappingdefinition[GO:1904355]  
2
  • BHF-UCL
Positive regulation of telomere maintenance via telomerasedefinition[GO:0032212]  
2
  • BHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It is regulated in the following manner
Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).  
1
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK15
GenomeRNAi: 225689
PRO: PR:Q8TD08
Chemistry
GuidetoPHARMACOLOGY: 2090