TRPM4 - Transient receptor potential cation channel subfamily M member 4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
TRPM4 »  Transient receptor potential cation channel subfamily M member 4
 
Protein also known as:  Calcium-activated non-selective cation channel 1.
Gene name:  TRPM4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 51 3
GENE REF ISO

Function

 show evidences
Overview 
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.5.4  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium activated cation channel activitydefinition[GO:0005227]  
  • ISSOrtholog Curator
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
GO biological process 
Dendritic cell chemotaxisdefinition[GO:0002407]  
  • ISSOrtholog Curator
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Protein sumoylationdefinition[GO:0016925]  
1
  • IDAUniProtKB
Regulation of T cell cytokine productiondefinition[GO:0002724]  
1
  • IDAUniProtKB
Enzymatic activity 
It is regulated in the following manner
Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).  
5
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPM4
GenomeRNAi: 54795
PRO: PR:Q8TD43
Chemistry
GuidetoPHARMACOLOGY: 496