BRSK1 - Serine/threonine-protein kinase BRSK1 - human protein (Function)
 
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BRSK1 »  Serine/threonine-protein kinase BRSK1   [ EC 2.7.11.1 ]
 
Protein also known as:  Brain-specific serine/threonine-protein kinase 1 (BR serine/threonine-protein kinase 1).
Gene name:  BRSK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • ICUniProtKB
Gamma-tubulin bindingdefinition[GO:0043015]  
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
GO biological process 
Axonogenesisdefinition[GO:0007409]  
  • ISSOrtholog Curator
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Centrosome duplicationdefinition[GO:0051298]  
  • ISSOrtholog Curator
Establishment of cell polaritydefinition[GO:0030010]  
  • ISSOrtholog Curator
G2 DNA damage checkpointdefinition[GO:0031572]  
1
  • IDAUniProtKB
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Neurotransmitter secretiondefinition[GO:0007269]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Not  Response to ionizing radiationdefinition[GO:0010212]  
1
  • IDAUniProtKB
Response to UVdefinition[GO:0009411]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
EC 2.7.11.26: ATP + [tau protein] ADP + [tau protein] phosphate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-189 by STK11/LKB1.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BRSK1
GenomeRNAi: 84446
PRO: PR:Q8TDC3
Chemistry
GuidetoPHARMACOLOGY: 1946