ACER1 - Alkaline ceramidase 1 - human protein (Function)
 
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ACER1 »  Alkaline ceramidase 1   [ EC 3.5.1.23 ]  (AlkCDase 1)
 
Protein also known as:  N-acylsphingosine amidohydrolase 3.
Gene name:  ACER1
Family name: Alkaline ceramidase
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 14 1
GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Ceramidase activitydefinition[GO:0017040]  
1
  • IDABHF-UCL
Dihydroceramidase activitydefinition[GO:0071633]  
1
  • IDABHF-UCL
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • IMPBHF-UCL
Cellular response to calcium iondefinition[GO:0071277]  
1
  • IDABHF-UCL
Ceramide catabolic processdefinition[GO:0046514]  
  • ISSOrtholog Curator
Epidermis developmentdefinition[GO:0008544]  
1
  • IEPBHF-UCL
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IEPBHF-UCL
Regulation of lipid metabolic processdefinition[GO:0019216] silver  
  • IEAOrtholog Compara
Response to alkaline pHdefinition[GO:0010446]  
1
  • IDABHF-UCL
Sphingolipid biosynthetic processdefinition[GO:0030148]  
1
  • IDABHF-UCL
Sphingolipid metabolic processdefinition[GO:0006665]  
  • ISSOrtholog Curator
Sphingosine biosynthetic processdefinition[GO:0046512]  
2
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.23: N-acylsphingosine + H(2)O a carboxylate + sphingosine.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by sphingosine (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+125981  
Sphingolipid metabolism  hsa00600+125981  
According to Reactome, this protein belongs to the following pathway:
Sphingolipid de novo biosynthesis  REACT_115810  
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACER1
GenomeRNAi: 125981
PRO: PR:Q8TDN7