ACMSD - 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase - human protein (Function)
 
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Protein
Gene
References

 
ACMSD »  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase   [ EC 4.1.1.45 ]
 
Protein also known as:  Picolinate carboxylase.
Gene name:  ACMSD
Family name: ACMSD
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.  
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  • CuratedUniProtKB
GO molecular function 
Aminocarboxymuconate-semialdehyde decarboxylase activitydefinition[GO:0001760]  
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  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Quinolinate metabolic processdefinition[GO:0046874]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.45: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate 2-aminomuconate semialdehyde + CO(2).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+130013  
Tryptophan metabolism  hsa00380+130013  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 130013
PRO: PR:Q8TDX5