NEK7 - Serine/threonine-protein kinase Nek7 - human protein (Function)
 
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NEK7 »  Serine/threonine-protein kinase Nek7   [ EC 2.7.11.1 ]
 
Protein also known as:  Never in mitosis A-related kinase 7 (NimA-related protein kinase 7).
Gene name:  NEK7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • RefGenome
  • Ortholog Curator
GO biological process 
Cytokinesisdefinition[GO:0000910]  
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  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
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  • UniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346]  
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  • UniProtKB
Spindle assemblydefinition[GO:0051225]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+)  
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  • UniProtKB
It is regulated in the following manner
Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.  
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  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of NIMA Kinases NEK9, NEK6, NEK7  REACT_160122  
Nuclear Pore Complex (NPC) Disassembly  REACT_163931  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 140609
PRO: PR:Q8TDX7
Chemistry
GuidetoPHARMACOLOGY: 2122