LMX1A - LIM homeobox transcription factor 1-alpha - human protein (Function)
 
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LMX1A »  LIM homeobox transcription factor 1-alpha
 
Protein also known as:  LIM/homeobox protein LMX1A.
Gene name:  LMX1A
Entry whose protein(s) existence is based on evidence at transcript level
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1 29 2
GENE REF ISO

Function

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Overview 
Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).  
1
  • UniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
1
  • Ortholog Compara
Central nervous system neuron differentiationdefinition[GO:0021953] silver  
1
  • Ortholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
1
  • Ortholog Compara
Dentate gyrus developmentdefinition[GO:0021542] silver  
1
  • Ortholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
1
  • Ortholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
1
  • Ortholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Regulation of cell growthdefinition[GO:0001558] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LMX1A
GenomeRNAi: 4009
PRO: PR:Q8TE12