LMX1A - LIM homeobox transcription factor 1-alpha - human protein (Function)
 
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LMX1A »  LIM homeobox transcription factor 1-alpha
 
Protein also known as:  LIM/homeobox protein LMX1A.
Gene name:  LMX1A
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Central nervous system neuron differentiationdefinition[GO:0021953] silver  
  • IEAOrtholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
  • IEAOrtholog Compara
Dentate gyrus developmentdefinition[GO:0021542] silver  
  • IEAOrtholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LMX1A
GenomeRNAi: 4009
PRO: PR:Q8TE12