ADAMTS18 - A disintegrin and metalloproteinase with thrombospondin motifs 18 - human protein (Function)
 
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ADAMTS18 »  A disintegrin and metalloproteinase with thrombospondin motifs 18   [ EC 3.4.24.- ]  (ADAMTS-18)
 
Gene name:  ADAMTS18
Entry whose protein(s) existence is based on evidence at protein level
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1 41 2
GENE REF ISO

Function

 show evidences
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Eye developmentdefinition[GO:0001654]  
1
  • IMPUniProtKB
Negative regulation of platelet aggregationdefinition[GO:0090331]  
1
  • IDAMGI
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Degradation of the extracellular matrix  REACT_201925  
Degradation of the extracellular matrix  REACT_118572  
O-glycosylation of TSR domain-containing proteins  REACT_200626  
Caution 
Variant Leu-179 has been originally reported as disease-causing mutation in a patient with Knobloch syndrome (PubMed21862674). It has been subsequently shown that Knobloch syndrome in the patient was due to an intronic mutation in COL18A1. Variant Leu-179 is, therefore, not responsible for the disease phenotype (PubMed23667181).  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 170692
PRO: PR:Q8TE60