PXYLP1 - 2-phosphoxylose phosphatase 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PXYLP1 »  2-phosphoxylose phosphatase 1   [ EC 3.1.3.- ]
 
Protein also known as:  Acid phosphatase-like protein 2.
Gene name:  PXYLP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 2
GENE REF ISO

Function

 show evidences
Overview 
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.  
2
  • UniProtKB
GO molecular function 
Acid phosphatase activitydefinition[GO:0003993] silver  
1
  • InterPro 2 GO
Phosphatase activitydefinition[GO:0016791]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Chondroitin sulfate proteoglycan biosynthetic processdefinition[GO:0050650]  
1
  • UniProtKB
Dephosphorylationdefinition[GO:0016311]  
2
  • GOC
  • InterPro 2 GO
Glycosaminoglycan biosynthetic processdefinition[GO:0006024]  
1
  • UniProtKB
Positive regulation of heparan sulfate proteoglycan biosynthetic processdefinition[GO:0010909]  
1
  • UniProtKB
 

Biophysicochemical properties

Dependence
pH Optimum pH is 5.8.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 92370
PRO: PR:Q8TE99