NUP210 - Nuclear pore membrane glycoprotein 210 - human protein (Function)
 
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NUP210 »  Nuclear pore membrane glycoprotein 210  (Nuclear pore protein gp210)
 
Protein also known as:  Nuclear envelope pore membrane protein POM 210 (POM210).
Gene name:  NUP210
Family name: NUP210
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.  
2
  • UniProtKB
GO molecular function 
Protein dimerization activitydefinition[GO:0046983] silver  
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  • Ortholog Compara
GO biological process 
mRNA transportdefinition[GO:0051028]  
1
  • UniProtKB KW
Protein transportdefinition[GO:0015031]  
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  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+23225  
According to Reactome, this protein belongs to the following pathways:
ISG15 antiviral mechanism  R-HSA-1169408  
Nuclear import of Rev protein  R-HSA-180746  
Nuclear Pore Complex (NPC) Disassembly  R-HSA-3301854  
Regulation of Glucokinase by Glucokinase Regulatory Protein  R-HSA-170822  
Regulation of HSF1-mediated heat shock response  R-HSA-3371453  
Rev-mediated nuclear export of HIV RNA  R-HSA-165054  
SUMOylation of DNA damage response and repair proteins  R-HSA-3108214  
Transcriptional regulation by small RNAs  R-HSA-5578749  
Viral Messenger RNA Synthesis  R-HSA-168325  
Vpr-mediated nuclear import of PICs  R-HSA-180910  
Note 
Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.  
1
  • UniProtKB
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Translocation  definition   [KW-0811]
Transport  definition   [KW-0813]
mRNA transport  definition   [KW-0509]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23225
PRO: PR:Q8TEM1