CREB3L4 - Cyclic AMP-responsive element-binding protein 3-like protein 4 - human protein (Function)
 
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CREB3L4 »  Cyclic AMP-responsive element-binding protein 3-like protein 4  (cAMP-responsive element-binding protein 3-like protein 4)
 
Protein also known as:  Transcript induced in spermiogenesis protein 40 (Tisp40). Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 4.
Gene name:  CREB3L4
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+148327  
Dopaminergic synapse  hsa04728+148327  
Huntington's disease  hsa05016+148327  
Melanogenesis  hsa04916+148327  
Prostate cancer  hsa05215+148327  
Vasopressin-regulated water reabsorption  hsa04962+148327  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 148327
PRO: PR:Q8TEY5