UBASH3B - Ubiquitin-associated and SH3 domain-containing protein B - human protein (Function)
 
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UBASH3B »  Ubiquitin-associated and SH3 domain-containing protein B   [ EC 3.1.3.48 ]
 
Protein also known as:  Suppressor of T-cell receptor signaling 1 (STS-1).
Gene name:  UBASH3B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
  • IEAEC 2 GO
GO biological process 
Negative regulation of platelet aggregationdefinition[GO:0090331] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335] silver  
  • IEAOrtholog Compara
Regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051279] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STS-1_(gene)
GenomeRNAi: 84959
PRO: PR:Q8TF42