AEN - Apoptosis-enhancing nuclease - human protein (Function)
 
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Protein
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References

 
AEN »  Apoptosis-enhancing nuclease   [ EC 3.1.-.- ]
 
Protein also known as:  Interferon-stimulated 20 kDa exonuclease-like 1.
Gene name:  AEN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.  
2
  • CuratedUniProtKB
GO molecular function 
Exonuclease activitydefinition[GO:0004527]  
2
  • IDAUniProtKB
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
GO biological process 
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • IDAUniProtKB
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
2
  • IDAGOC
Response to ionizing radiationdefinition[GO:0010212]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
DNA damage  definition   [KW-0227]
Molecular function 
Exonuclease  definition   [KW-0269]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64782
PRO: PR:Q8WTP8