GRK7 - G protein-coupled receptor kinase 7 - human protein (Function)
 
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GRK7 »  G protein-coupled receptor kinase 7   [ EC 2.7.11.16EC 2.7.11.14 ]
 
Protein also known as:  G protein-coupled receptor kinase GRK7.
Gene name:  GRK7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
G-protein coupled receptor kinase activitydefinition[GO:0004703]  
  • IEAEC 2 GO
Rhodopsin kinase activitydefinition[GO:0050254]  
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  • IDAUniProtKB
GO biological process 
Protein autophosphorylationdefinition[GO:0046777]  
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  • IMPUniProtKB
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.16: ATP + [G-protein-coupled receptor] ADP + [G-protein-coupled receptor] phosphate.  
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  • CuratedUniProtKB
EC 2.7.11.14: ATP + [rhodopsin] ADP + [rhodopsin] phosphate.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by phosphorylation of Ser-36 (By similarity).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+131890  
Endocytosis  hsa04144+131890  
Phototransduction  hsa04744+131890  
Note 
Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 1.9 uM for rhodopsin
KM 21.4 uM for ATP
Vmax 915 nmol/min/mg enzyme

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 131890
PRO: PR:Q8WTQ7
Chemistry
GuidetoPHARMACOLOGY: 1471