ABHD5 - 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 - human protein (Function)
 
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ABHD5 »  1-acylglycerol-3-phosphate O-acyltransferase ABHD5   [ EC 2.3.1.51 ]
 
Protein also known as:  Abhydrolase domain-containing protein 5.
Gene name:  ABHD5
Family name: Peptidase S33 » ABHD4/ABHD5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.  
4
  • UniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
1
  • EC 2 GO
Lysophosphatidic acid acyltransferase activitydefinition[GO:0042171]  
1
  • UniProtKB
Not  Triglyceride lipase activitydefinition[GO:0004806]  
1
  • Ortholog Curator
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Fatty acid metabolic processdefinition[GO:0006631]  
1
  • UniProtKB KW
Negative regulation of sequestering of triglyceridedefinition[GO:0010891]  
1
  • UniProtKB
Phosphatidic acid biosynthetic processdefinition[GO:0006654]  
1
  • UniProtKB
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006] silver  
1
  • Ortholog Compara
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  REACT_494  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABHD5
GenomeRNAi: 51099
PRO: PR:Q8WTS1