ABHD5 - 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ABHD5 »  1-acylglycerol-3-phosphate O-acyltransferase ABHD5   [ EC 2.3.1.51 ]
 
Protein also known as:  Abhydrolase domain-containing protein 5.
Gene name:  ABHD5
Family name: Peptidase S33 » ABHD4/ABHD5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

 show evidences
Overview 
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.  
3
  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
  • IEAEC 2 GO
Lysophosphatidic acid acyltransferase activitydefinition[GO:0042171]  
1
  • IDAUniProtKB
Not  Triglyceride lipase activitydefinition[GO:0004806]  
  • ISSOrtholog Curator
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Negative regulation of sequestering of triglyceridedefinition[GO:0010891]  
1
  • IDAUniProtKB
Phosphatidic acid biosynthetic processdefinition[GO:0006654]  
1
  • IDAUniProtKB
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006] silver  
  • IEAOrtholog Compara
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  REACT_494  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABHD5
GenomeRNAi: 51099
PRO: PR:Q8WTS1