ABHD3 - Phospholipase ABHD3 - human protein (Function)
 
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ABHD3 »  Phospholipase ABHD3   [ EC 3.1.1.32EC 3.1.1.4 ]
 
Protein also known as:  Abhydrolase domain-containing protein 3.
Gene name:  ABHD3
Family name: AB hydrolase » UPF0017
Entry whose protein(s) existence is based on evidence at protein level
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1 18 2
GENE REF ISO

Function

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Overview 
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.  
2
  • UniProtKB
GO molecular function 
1-acyl-2-lysophosphatidylserine acylhydrolase activitydefinition[GO:0052740]  
1
  • EC 2 GO
Phosphatidylcholine 1-acylhydrolase activitydefinition[GO:0008970]  
1
  • UniProtKB
Phosphatidylserine 1-acylhydrolase activitydefinition[GO:0052739]  
1
  • EC 2 GO
Phospholipase A2 activitydefinition[GO:0004623]  
1
  • UniProtKB
GO biological process 
Phosphatidylcholine metabolic processdefinition[GO:0046470]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.1.4: Phosphatidylcholine + H(2)O 1-acylglycerophosphocholine + a carboxylate.  
2
  • UniProtKB
EC 3.1.1.32: Phosphatidylcholine + H(2)O 2-acylglycerophosphocholine + a carboxylate.  
2
  • UniProtKB
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 171586
PRO: PR:Q8WU67