SLC20A1 - Sodium-dependent phosphate transporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC20A1 »  Sodium-dependent phosphate transporter 1
 
Protein also known as:  Gibbon ape leukemia virus receptor 1 (GLVR-1).
Gene name:  SLC20A1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the inorganic phosphate transporter (pit) family  2.A.20.2.7  
GO molecular function 
High affinity inorganic phosphate:sodium symporter activitydefinition[GO:0005316] silver  
  • IEAOrtholog Compara
Inorganic phosphate transmembrane transporter activitydefinition[GO:0005315] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
Sodium:phosphate symporter activitydefinition[GO:0005436]  
1
  • TASPINC
GO biological process 
Phosphate ion transmembrane transportdefinition[GO:0035435]  
1
  • TASGOC
Phosphate-containing compound metabolic processdefinition[GO:0006796]  
1
  • TASPINC
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IMPGOC
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Biophysicochemical properties

Kinetic parameters
With an increase in pH, a decrease in phosphate uptake is observed.
KM 24.1 uM for phosphate
Vmax 1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate)
Dependence
pH Optimum pH is 6.5 and 7.5.

Keywords

Biological process 
Phosphate transport  definition   [KW-0592]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC20A1
GenomeRNAi: 6574
PRO: PR:Q8WUM9