BLNK - B-cell linker protein - human protein (Function)
 
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Protein
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References

 
BLNK »  B-cell linker protein
 
Protein also known as:  Src homology 2 domain-containing leukocyte protein of 65 kDa (SLP-65).
Gene name:  BLNK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 3
GENE REF ISO

Function

 show evidences
Overview 
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.  
4
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070]  
2
  • RCAUniProtKB
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
1
  • TASPINC
GO biological process 
B cell differentiationdefinition[GO:0030183]  
1
  • NASUniProtKB
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Positive regulation of signal transductiondefinition[GO:0009967]  
2
  • RCAGOC
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+29760  
Osteoclast differentiation  hsa04380+29760  
Primary immunodeficiency  hsa05340+29760  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
Regulation of signaling by CBL  REACT_23787  
 

Keywords

Biological process 
B-cell activation  definition   [KW-0075]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: B-cell_linker
GenomeRNAi: 29760
PRO: PR:Q8WV28