UBE2Q2 - Ubiquitin-conjugating enzyme E2 Q2 - human protein (Function)
 
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UBE2Q2 »  Ubiquitin-conjugating enzyme E2 Q2   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin carrier protein Q2.
Gene name:  UBE2Q2
Entry whose protein(s) existence is based on evidence at protein level
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1 17 4
GENE REF ISO

Function

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Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.  
1
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+92912  
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 92912
PRO: PR:Q8WVN8