CANT1 - Soluble calcium-activated nucleotidase 1 - human protein (Function)
 
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CANT1 »  Soluble calcium-activated nucleotidase 1   [ EC 3.6.1.6 ]  (SCAN-1)
 
Protein also known as:  Putative NF-kappa-B-activating protein 107.
Gene name:  CANT1
Family name: Apyrase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 2
GENE REF ISO

Function

 show evidences
Overview 
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.  
3
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
Uridine-diphosphatase activitydefinition[GO:0045134]  
  • IEAEC 2 GO
GO biological process 
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Proteoglycan biosynthetic processdefinition[GO:0030166]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IMPGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.6: A nucleoside diphosphate + H(2)O a nucleoside phosphate + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Purine metabolism  hsa00230+124583  
Pyrimidine metabolism  hsa00240+124583  
Note 
Not inhibited by azide.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Dependence
pH Optimum pH is 6.8.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CANT1
GenomeRNAi: 124583
PRO: PR:Q8WVQ1