APH1B - Gamma-secretase subunit APH-1B - human protein (Function)
 
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APH1B »  Gamma-secretase subunit APH-1B  (APH-1b)
 
Protein also known as:  Presenilin-stabilization factor-like.
Gene name:  APH1B
Family name: APH-1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.  
1
  • CuratedUniProtKB
GO molecular function 
Peptidase activitydefinition[GO:0008233]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Positive regulation of catalytic activitydefinition[GO:0043085] silver  
  • IEAInterPro 2 GO
Protein processingdefinition[GO:0016485]  
1
  • IDAMGI
Pathways 
According to Reactome, this protein belongs to the following pathways:
A third proteolytic cleavage releases NICD  REACT_691  
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 83464
PRO: PR:Q8WW43