NRG4 - Pro-neuregulin-4, membrane-bound isoform - human protein (Function)
 
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Protein
Gene
References

 
NRG4 »  Pro-neuregulin-4, membrane-bound isoform  (Pro-NRG4)
 
Cleaved into:  Neuregulin-4.
Gene name:  NRG4
Family name: Neuregulin
Entry whose protein(s) existence is based on evidence at transcript level
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1 13 1
GENE REF ISO

Function

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Overview 
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
ErbB signaling pathway  hsa04012+145957  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NRG4
GenomeRNAi: 145957
PRO: PR:Q8WWG1