NRG4 - Pro-neuregulin-4, membrane-bound isoform - human protein (Function)
 
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NRG4 »  Pro-neuregulin-4, membrane-bound isoform  (Pro-NRG4)
 
Cleaved into:  Neuregulin-4.
Gene name:  NRG4
Family name: Neuregulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).  
1
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
1
  • RefGenome
Organ developmentdefinition[GO:0048513]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
ErbB signaling pathway  hsa04012+145957  
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
GRB2 events in ERBB2 signaling  R-HSA-1963640  
Nuclear signaling by ERBB4  R-HSA-1251985  
PI3K events in ERBB2 signaling  R-HSA-1963642  
PI3K events in ERBB4 signaling  R-HSA-1250342  
PIP3 activates AKT signaling  R-HSA-1257604  
RAF/MAP kinase cascade  R-HSA-5673001  
SHC1 events in ERBB2 signaling  R-HSA-1250196  
SHC1 events in ERBB4 signaling  R-HSA-1250347  
Signaling by ERBB2  R-HSA-1227986  
Signaling by ERBB4  R-HSA-1236394  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NRG4
GenomeRNAi: 145957
PRO: PR:Q8WWG1