HPSE2 - Inactive heparanase-2 - human protein (Function)
 
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Protein
Gene
References

 
HPSE2 »  Inactive heparanase-2  (Hpa2)
 
Gene name:  HPSE2
Family name: Glycosyl hydrolase 79
Entry whose protein(s) existence is based on evidence at protein level
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1 34 4
GENE REF ISO

Function

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Overview 
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).  
1
  • CuratedUniProtKB
GO molecular function 
Heparan sulfate proteoglycan bindingdefinition[GO:0043395]  
1
  • IDAUniProtKB
Contradiction  Heparanase activitydefinition[GO:0030305]  
2
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan degradation  hsa00531+60495  
Metabolic pathways  hsa01100+60495  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HPSE2
GenomeRNAi: 60495
PRO: PR:Q8WWQ2