LIPH - Lipase member H - human protein (Function)
 
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LIPH »  Lipase member H   [ EC 3.1.1.- ]  (LIPH)
 
Protein also known as:  Membrane-associated phosphatidic acid-selective phospholipase A1-alpha (mPA-PLA1 alpha).
Gene name:  LIPH
Family name: AB hydrolase » Lipase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).  
2
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Phospholipase activitydefinition[GO:0004620]  
1
  • IDAUniProtKB
GO biological process 
Lipid catabolic processdefinition[GO:0016042]  
1
  • IDAUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by sodium vanadate.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LIPH
GenomeRNAi: 200879
PRO: PR:Q8WWY8