RXFP2 - Relaxin receptor 2 - human protein (Function)
 
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RXFP2 »  Relaxin receptor 2
 
Protein also known as:  Leucine-rich repeat-containing G-protein coupled receptor 8.
Gene name:  RXFP2
Entry whose protein(s) existence is based on evidence at protein level
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1 36 2
GENE REF ISO

Function

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Overview 
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).  
  • CuratedUniProtKB
GO molecular function 
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein-hormone receptor activitydefinition[GO:0016500] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Oocyte maturationdefinition[GO:0001556] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+122042  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Relaxin receptors  REACT_21314  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Relaxin/insulin-like_family_peptide_receptor_2
GenomeRNAi: 122042
PRO: PR:Q8WXD0
Chemistry
GuidetoPHARMACOLOGY: 352