DEDD2 - DNA-binding death effector domain-containing protein 2 - human protein (Function)
 
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Protein
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References

 
DEDD2 »  DNA-binding death effector domain-containing protein 2
 
Protein also known as:  FADD-like anti-apoptotic molecule 3.
Gene name:  DEDD2
Entry whose protein(s) existence is based on evidence at protein level
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1 12 2
GENE REF ISO

Function

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Overview 
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • NASUniProtKB
GO biological process 
Apoptotic nuclear changesdefinition[GO:0030262]  
1
  • IDAUniProtKB
Cellular homeostasisdefinition[GO:0019725]  
1
  • NASUniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IMPUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • NASUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • NASUniProtKB
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPUniProtKB
RNA processingdefinition[GO:0006396]  
1
  • NASUniProtKB
rRNA catabolic processdefinition[GO:0016075]  
1
  • NASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 162989
PRO: PR:Q8WXF8