ADAMTS14 - A disintegrin and metalloproteinase with thrombospondin motifs 14 - human protein (Function)
 
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ADAMTS14 »  A disintegrin and metalloproteinase with thrombospondin motifs 14   [ EC 3.4.24.- ]  (ADAMTS-14)
 
Gene name:  ADAMTS14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.  
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Collagen catabolic processdefinition[GO:0030574]  
  • IEAUniProtKB KW
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 140766
PRO: PR:Q8WXS8