ARNTL2 - Aryl hydrocarbon receptor nuclear translocator-like protein 2 - human protein (Function)
 
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ARNTL2 »  Aryl hydrocarbon receptor nuclear translocator-like protein 2
 
Protein also known as:  Class E basic helix-loop-helix protein 6 (bHLHe6).
Gene name:  ARNTL2
Entry whose protein(s) existence is based on evidence at protein level
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1 27 9
GENE REF ISO

Function

 show evidences
Overview 
ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAMGI
  • NASUniProtKB
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Circadian rhythmdefinition[GO:0007623]  
1
  • IDAMGI
Entrainment of circadian clockdefinition[GO:0009649]  
1
  • NASUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IDAMGI
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAGOC
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARNTL2
GenomeRNAi: 56938
PRO: PR:Q8WYA1