KAT6B - Histone acetyltransferase KAT6B - human protein (Function)
 
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KAT6B »  Histone acetyltransferase KAT6B   [ EC 2.3.1.48 ]
 
Protein also known as:  Monocytic leukemia zinc finger protein-related factor.
Gene name:  KAT6B
Family name: MYST (SAS/MOZ)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.  
4
  • UniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Histone acetylationdefinition[GO:0016573]  
1
  • UniProtKB
Histone H3 acetylationdefinition[GO:0043966]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Nucleosome assemblydefinition[GO:0006334]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_264245  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYST4
GenomeRNAi: 23522
PRO: PR:Q8WYB5