ACOT12 - Acyl-coenzyme A thioesterase 12 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ACOT12 »  Acyl-coenzyme A thioesterase 12   [ EC 3.1.2.1 ]  (Acyl-CoA thioesterase 12)
 
Protein also known as:  Cytoplasmic acetyl-CoA hydrolase 1 (CACH-1).
Gene name:  ACOT12
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 14 1
GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes acetyl-CoA to acetate and CoA.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the acyl-coa thioesterase (acot) family  4.C.3.1.2  
GO molecular function 
Acetyl-CoA hydrolase activitydefinition[GO:0003986]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Lipid bindingdefinition[GO:0008289] silver  
  • IEAInterPro 2 GO
GO biological process 
Acetyl-CoA metabolic processdefinition[GO:0006084] silver  
  • IEAOrtholog Compara
Acyl-CoA metabolic processdefinition[GO:0006637]  
  • ISSOrtholog Curator
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Pyruvate metabolic processdefinition[GO:0006090]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.2.1: Acetyl-CoA + H(2)O CoA + acetate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by ADP. Active in the presence of ATP.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Pyruvate metabolism  hsa00620+134526  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q8WYK0
Other
GeneWiki: ACOT12
GenomeRNAi: 134526
PRO: PR:Q8WYK0