JDP2 - Jun dimerization protein 2 - human protein (Function)
 
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JDP2 »  Jun dimerization protein 2
 
Gene name:  JDP2
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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1 25 2
GENE REF ISO

Function

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Overview 
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.  
4
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of histone deacetylationdefinition[GO:0031065] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: JDP2_(gene)
GeneWiki: Jun_dimerization_protein
GenomeRNAi: 122953
PRO: PR:Q8WYK2