PIK3R5 - Phosphoinositide 3-kinase regulatory subunit 5 - human protein (Function)
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PIK3R5 »  Phosphoinositide 3-kinase regulatory subunit 5  (PI3-kinase regulatory subunit 5)
Protein also known as:  Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit (PtdIns-3-kinase regulatory subunit).
Gene name:  PIK3R5
Entry whose protein(s) existence is based on evidence at protein level
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Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).  
  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase regulator activitydefinition[GO:0046935] silver  
  • IEAOrtholog Compara
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683]  
  • ISSOrtholog Curator
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
  • ISSOrtholog Curator
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
  • ISSOrtholog Curator
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
  • ISSOrtholog Curator
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Greatly activated by G gamma proteins (By similarity).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+23533  
Aldosterone-regulated sodium reabsorption  hsa04960+23533  
Amoebiasis  hsa05146+23533  
Apoptosis  hsa04210+23533  
B cell receptor signaling pathway  hsa04662+23533  
Bacterial invasion of epithelial cells  hsa05100+23533  
Carbohydrate digestion and absorption  hsa04973+23533  
Chagas disease (American trypanosomiasis)  hsa05142+23533  
Chemokine signaling pathway  hsa04062+23533  
Cholinergic synapse  hsa04725+23533  
Chronic myeloid leukemia  hsa05220+23533  
Colorectal cancer  hsa05210+23533  
Endometrial cancer  hsa05213+23533  
ErbB signaling pathway  hsa04012+23533  
Fc epsilon RI signaling pathway  hsa04664+23533  
Fc gamma R-mediated phagocytosis  hsa04666+23533  
Focal adhesion  hsa04510+23533  
Glioma  hsa05214+23533  
Hepatitis C  hsa05160+23533  
HTLV-I infection  hsa05166+23533  
Influenza A  hsa05164+23533  
Insulin signaling pathway  hsa04910+23533  
Jak-STAT signaling pathway  hsa04630+23533  
Leukocyte transendothelial migration  hsa04670+23533  
Measles  hsa05162+23533  
Melanoma  hsa05218+23533  
mTOR signaling pathway  hsa04150+23533  
Natural killer cell mediated cytotoxicity  hsa04650+23533  
Neurotrophin signaling pathway  hsa04722+23533  
Non-small cell lung cancer  hsa05223+23533  
Osteoclast differentiation  hsa04380+23533  
Pancreatic cancer  hsa05212+23533  
Pathways in cancer  hsa05200+23533  
Phosphatidylinositol signaling system  hsa04070+23533  
Progesterone-mediated oocyte maturation  hsa04914+23533  
Prostate cancer  hsa05215+23533  
Regulation of actin cytoskeleton  hsa04810+23533  
Renal cell carcinoma  hsa05211+23533  
Small cell lung cancer  hsa05222+23533  
T cell receptor signaling pathway  hsa04660+23533  
Toll-like receptor signaling pathway  hsa04620+23533  
Toxoplasmosis  hsa05145+23533  
Type II diabetes mellitus  hsa04930+23533  
VEGF signaling pathway  hsa04370+23533  
According to Reactome, this protein belongs to the following pathways:
G beta:gamma signalling through PI3Kgamma  REACT_19290  
GPVI-mediated activation cascade  REACT_1695  
Synthesis of PIPs at the plasma membrane  REACT_121025  
More information is available from:


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PIK3R5
GenomeRNAi: 23533