DDB2 - DNA damage-binding protein 2 - human protein (Function)
 
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Protein
Gene
References

 
DDB2 »  DNA damage-binding protein 2
 
Gene name:  DDB2
Family name: WD repeat DDB2/WDR76
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 93 5
GENE REF ISO

Function

 show evidences
Overview 
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.  
12
  • CuratedUniProtKB
Isoforms  D1 and D2   Inhibit UV-damaged DNA repair.  
12
  • CuratedUniProtKB
GO molecular function 
Contributes to damaged DNA bindingdefinition[GO:0003684]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Contributes to ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Histone H2A monoubiquitinationdefinition[GO:0035518]  
1
  • IDAUniProtKB
Protein autoubiquitinationdefinition[GO:0051865]  
1
  • IDAUniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • IDAUniProtKB
Pyrimidine dimer repairdefinition[GO:0006290] silver  
  • IEAOrtholog Compara
Response to UVdefinition[GO:0009411]  
1
  • IDAUniProtKB
UV-damage excision repairdefinition[GO:0070914]  
1
  • IDAUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Nucleotide excision repair  hsa03420+1643  
p53 signaling pathway  hsa04115+1643  
Ubiquitin mediated proteolysis  hsa04120+1643  
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Formation of incision complex in GG-NER  REACT_257  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DDB2
GenomeRNAi: 1643
PRO: PR:Q92466