AQP3 - Aquaporin-3 - human protein (Function)
 
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AQP3 »  Aquaporin-3  (AQP-3)
 
Protein also known as:  Aquaglyceroporin-3.
Gene name:  AQP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 2
GENE REF ISO

Function

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Overview 
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Glycerol channel activitydefinition[GO:0015254]  
1
  • IDABHF-UCL
Transporter activitydefinition[GO:0005215]  
1
  • NASPINC
Water channel activitydefinition[GO:0015250]  
1
  • TASBHF-UCL
GO biological process 
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Odontogenesisdefinition[GO:0042476]  
1
  • IEPUniProtKB
Positive regulation of immune system processdefinition[GO:0002684]  
1
  • IDABHF-UCL
Regulation of keratinocyte differentiationdefinition[GO:0045616]  
1
  • TASBHF-UCL
Renal water absorptiondefinition[GO:0070295] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592]  
1
  • TASBHF-UCL
Response to retinoic aciddefinition[GO:0032526]  
1
  • IDABHF-UCL
Response to vitamin Ddefinition[GO:0033280]  
1
  • TASBHF-UCL
Transportdefinition[GO:0006810]  
1
  • NASPINC
Urea transportdefinition[GO:0015840] silver  
  • IEAOrtholog Compara
Water transportdefinition[GO:0006833]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vasopressin-regulated water reabsorption  hsa04962+360  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aquaporin_3
GenomeRNAi: 360
PRO: PR:Q92482
Chemistry
GuidetoPHARMACOLOGY: 690