TRIB2 - Tribbles homolog 2 - human protein (Function)
 
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TRIB2 »  Tribbles homolog 2  (TRB-2)
 
Gene name:  TRIB2
Entry whose protein(s) existence is based on evidence at protein level
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1 45 1
GENE REF ISO

Function

 show evidences
Overview 
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Not  Nucleotide bindingdefinition[GO:0000166]  
  • ISSOrtholog Curator
Not  Protein kinase activitydefinition[GO:0004672]  
  • ISSOrtholog Curator
Protein kinase inhibitor activitydefinition[GO:0004860]  
  • IEAUniProtKB KW
Transcription factor bindingdefinition[GO:0008134]  
1
  • ISSBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • ISSBHF-UCL
Ubiquitin-protein transferase regulator activitydefinition[GO:0055106]  
1
  • ISSBHF-UCL
GO biological process 
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • ISSBHF-UCL
Negative regulation of interleukin-10 biosynthetic processdefinition[GO:0045081]  
1
  • IMPBHF-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • NASBHF-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • ISSBHF-UCL
Not  Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Regulation of MAP kinase activitydefinition[GO:0043405]  
  • ISSOrtholog Curator
 

Keywords

Molecular function 
Protein kinase inhibitor  definition   [KW-0649]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIB2
GenomeRNAi: 28951
PRO: PR:Q92519