PIGC - Phosphatidylinositol N-acetylglucosaminyltransferase subunit C - human protein (Function)
 
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PIGC »  Phosphatidylinositol N-acetylglucosaminyltransferase subunit C   [ EC 2.4.1.198 ]
 
Protein also known as:  Phosphatidylinositol-glycan biosynthesis class C protein (PIG-C).
Gene name:  PIGC
Family name: PIGC
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 15 1
GENE REF ISO

Function

 show evidences
Overview 
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.  
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824]  
1
  • TASPINC
Phosphatidylinositol N-acetylglucosaminyltransferase activitydefinition[GO:0017176]  
  • IEAEC 2 GO
GO biological process 
GPI anchor biosynthetic processdefinition[GO:0006506]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.198: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis  hsa00563+5279  
Metabolic pathways  hsa01100+5279  
According to Reactome, this protein belongs to the following pathway:
Synthesis of glycosylphosphatidylinositol (GPI)  REACT_952  
 

Keywords

Biological process 
GPI-anchor biosynthesis  definition   [KW-0337]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIGC
GenomeRNAi: 5279
PRO: PR:Q92535