SLC7A6 - Y+L amino acid transporter 2 - human protein (Function)
 
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Protein
Gene
References

 
SLC7A6 »  Y+L amino acid transporter 2
 
Protein also known as:  Cationic amino acid transporter, y+ system.
Gene name:  SLC7A6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the amino acid-polyamine-organocation (apc) family  2.A.3.8.23  
GO molecular function 
Amino acid transmembrane transporter activitydefinition[GO:0015171] silver  
  • IEAInterPro 2 GO
Antiporter activitydefinition[GO:0015297]  
  • IEAUniProtKB KW
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • TASPINC
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Amino acid and oligopeptide SLC transporters  REACT_19419  
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 120 uM for arginine (in the presence of NaCl)
KM 236 uM for leucine (in the presence of NaCl)
KM 138 uM for arginine (in the absence of NaCl)
KM 295 uM for glutamine (in the presence of NaCl)

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Antiport  definition   [KW-0050]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q92536
Other
GeneWiki: SLC7A6
GenomeRNAi: 9057
PRO: PR:Q92536