BAP1 - Ubiquitin carboxyl-terminal hydrolase BAP1 - human protein (Function)
 
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BAP1 »  Ubiquitin carboxyl-terminal hydrolase BAP1   [ EC 3.4.19.12 ]
 
Protein also known as:  BRCA1-associated protein 1.
Gene name:  BAP1
Family name: Peptidase C12 » BAP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed24703950). Acts as a tumor suppressor.  
9
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
5
  • UniProtKB
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
1
  • UniProtKB
Monoubiquitinated histone H2A deubiquitinationdefinition[GO:0035522]  
1
  • UniProtKB
Monoubiquitinated protein deubiquitinationdefinition[GO:0035520]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Positive regulation of protein targeting to mitochondriondefinition[GO:1903955]  
1
  • ParkinsonsUK-UCL
Protein deubiquitinationdefinition[GO:0016579]  
2
  • UniProtKB
Protein K48-linked deubiquitinationdefinition[GO:0071108]  
1
  • UniProtKB
Regulation of cell cycledefinition[GO:0051726]  
1
  • UniProtKB
Regulation of cell growthdefinition[GO:0001558]  
1
  • UniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
1
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAP1
GenomeRNAi: 8314
PRO: PR:Q92560