PIK3R3 - Phosphatidylinositol 3-kinase regulatory subunit gamma - human protein (Function)
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads

PIK3R3 »  Phosphatidylinositol 3-kinase regulatory subunit gamma  (PI3K regulatory subunit gamma)
Protein also known as:  Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma (PI3-kinase subunit p55-gamma).
Gene name:  PIK3R3
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 3


 show evidences
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.  
  • UniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303]  
  • PINC
1-phosphatidylinositol-3-kinase regulator activitydefinition[GO:0046935]  
  • RefGenome
Protein bindingdefinition[GO:0005515]  
  • IntAct
GO biological process 
Insulin receptor signaling pathwaydefinition[GO:0008286]  
  • PINC
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
  • RefGenome
Phosphatidylinositol-3-phosphate biosynthetic processdefinition[GO:0036092]  
  • GOC
Positive regulation of glucose import in response to insulin stimulusdefinition[GO:2001275]  
  • Ortholog Curator
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
  • RefGenome
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+8503  
Amoebiasis  hsa05146+8503  
Apoptosis  hsa04210+8503  
B cell receptor signaling pathway  hsa04662+8503  
Bacterial invasion of epithelial cells  hsa05100+8503  
Carbohydrate digestion and absorption  hsa04973+8503  
Chagas disease (American trypanosomiasis)  hsa05142+8503  
Chemokine signaling pathway  hsa04062+8503  
Cholinergic synapse  hsa04725+8503  
Chronic myeloid leukemia  hsa05220+8503  
Colorectal cancer  hsa05210+8503  
Endometrial cancer  hsa05213+8503  
ErbB signaling pathway  hsa04012+8503  
Fc epsilon RI signaling pathway  hsa04664+8503  
Fc gamma R-mediated phagocytosis  hsa04666+8503  
Focal adhesion  hsa04510+8503  
Glioma  hsa05214+8503  
Hepatitis C  hsa05160+8503  
HTLV-I infection  hsa05166+8503  
Influenza A  hsa05164+8503  
Insulin signaling pathway  hsa04910+8503  
Jak-STAT signaling pathway  hsa04630+8503  
Leukocyte transendothelial migration  hsa04670+8503  
Measles  hsa05162+8503  
Melanoma  hsa05218+8503  
mTOR signaling pathway  hsa04150+8503  
Natural killer cell mediated cytotoxicity  hsa04650+8503  
Neurotrophin signaling pathway  hsa04722+8503  
Non-small cell lung cancer  hsa05223+8503  
Osteoclast differentiation  hsa04380+8503  
Pancreatic cancer  hsa05212+8503  
Pathways in cancer  hsa05200+8503  
Phosphatidylinositol signaling system  hsa04070+8503  
Progesterone-mediated oocyte maturation  hsa04914+8503  
Prostate cancer  hsa05215+8503  
Regulation of actin cytoskeleton  hsa04810+8503  
Renal cell carcinoma  hsa05211+8503  
Small cell lung cancer  hsa05222+8503  
T cell receptor signaling pathway  hsa04660+8503  
Toll-like receptor signaling pathway  hsa04620+8503  
Toxoplasmosis  hsa05145+8503  
Type II diabetes mellitus  hsa04930+8503  
VEGF signaling pathway  hsa04370+8503  
According to Reactome, this protein belongs to the following pathways:
CD28 dependent PI3K/Akt signaling  R-HSA-389357  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
Costimulation by the CD28 family  R-HSA-388841  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (q) signalling events  R-HSA-416476  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
Interleukin-7 signaling  R-HSA-1266695  
PIP3 activates AKT signaling  R-HSA-1257604  
Regulation of signaling by CBL  R-HSA-912631  
Signaling by SCF-KIT  R-HSA-1433557  
Synthesis of PIPs at the plasma membrane  R-HSA-1660499  
More information is available from:


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PIK3R3
GenomeRNAi: 8503
PRO: PR:Q92569