PIK3R3 - Phosphatidylinositol 3-kinase regulatory subunit gamma - human protein (Function)
 
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PIK3R3 »  Phosphatidylinositol 3-kinase regulatory subunit gamma  (PI3K regulatory subunit gamma)
 
Protein also known as:  Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma (PI3-kinase subunit p55-gamma).
Gene name:  PIK3R3
Family name: PI3K p85 subunit
Entry whose protein(s) existence is based on evidence at protein level
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1 24 3
GENE REF ISO

Function

 show evidences
Overview 
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.  
  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303]  
1
  • TASPINC
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • TASPINC
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
1
  • TASGOC
Phosphatidylinositol-3-phosphate biosynthetic processdefinition[GO:0036092]  
1
  • TASGOC
Phosphorylationdefinition[GO:0016310]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+8503  
Amoebiasis  hsa05146+8503  
Apoptosis  hsa04210+8503  
B cell receptor signaling pathway  hsa04662+8503  
Bacterial invasion of epithelial cells  hsa05100+8503  
Carbohydrate digestion and absorption  hsa04973+8503  
Chagas disease (American trypanosomiasis)  hsa05142+8503  
Chemokine signaling pathway  hsa04062+8503  
Cholinergic synapse  hsa04725+8503  
Chronic myeloid leukemia  hsa05220+8503  
Colorectal cancer  hsa05210+8503  
Endometrial cancer  hsa05213+8503  
ErbB signaling pathway  hsa04012+8503  
Fc epsilon RI signaling pathway  hsa04664+8503  
Fc gamma R-mediated phagocytosis  hsa04666+8503  
Focal adhesion  hsa04510+8503  
Glioma  hsa05214+8503  
Hepatitis C  hsa05160+8503  
HTLV-I infection  hsa05166+8503  
Influenza A  hsa05164+8503  
Insulin signaling pathway  hsa04910+8503  
Jak-STAT signaling pathway  hsa04630+8503  
Leukocyte transendothelial migration  hsa04670+8503  
Measles  hsa05162+8503  
Melanoma  hsa05218+8503  
mTOR signaling pathway  hsa04150+8503  
Natural killer cell mediated cytotoxicity  hsa04650+8503  
Neurotrophin signaling pathway  hsa04722+8503  
Non-small cell lung cancer  hsa05223+8503  
Osteoclast differentiation  hsa04380+8503  
Pancreatic cancer  hsa05212+8503  
Pathways in cancer  hsa05200+8503  
Phosphatidylinositol signaling system  hsa04070+8503  
Progesterone-mediated oocyte maturation  hsa04914+8503  
Prostate cancer  hsa05215+8503  
Regulation of actin cytoskeleton  hsa04810+8503  
Renal cell carcinoma  hsa05211+8503  
Small cell lung cancer  hsa05222+8503  
T cell receptor signaling pathway  hsa04660+8503  
Toll-like receptor signaling pathway  hsa04620+8503  
Toxoplasmosis  hsa05145+8503  
Type II diabetes mellitus  hsa04930+8503  
VEGF signaling pathway  hsa04370+8503  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIK3R3
GenomeRNAi: 8503
PRO: PR:Q92569