SLC9A6 - Sodium/hydrogen exchanger 6 - human protein (Function)
 
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Protein
Gene
References

 
SLC9A6 »  Sodium/hydrogen exchanger 6
 
Protein also known as:  Solute carrier family 9 member 6.
Gene name:  SLC9A6
Entry whose protein(s) existence is based on evidence at protein level
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1 35 3
GENE REF ISO

Function

 show evidences
Overview 
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the monovalent cation:proton antiporter-1 (cpa1) family  2.A.36.1.14  
GO molecular function 
Sodium:hydrogen antiporter activitydefinition[GO:0015385] silver  
  • IEAInterPro 2 GO
GO biological process 
Axon extensiondefinition[GO:0048675]  
1
  • IDAMGI
Dendrite extensiondefinition[GO:0097484]  
1
  • IDAMGI
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • IDAMGI
Regulation of pHdefinition[GO:0006885] silver  
  • IEAInterPro 2 GO
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cardiac muscle contraction  hsa04260+10479  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Caution 
Was originally (PubMed9507001) identified as a mitochondrial inner membrane protein, but was later shown to be localized in early and recycling endosomes and not mitochondria (PubMed11940519).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC9A6
GenomeRNAi: 10479
PRO: PR:Q92581