LPAR1 - Lysophosphatidic acid receptor 1 - human protein (Function)
 
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LPAR1 »  Lysophosphatidic acid receptor 1  (LPA-1)
 
Protein also known as:  Lysophosphatidic acid receptor Edg-2.
Gene name:  LPAR1
Entry whose protein(s) existence is based on evidence at protein level
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1 74 2
GENE REF ISO

Function

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Overview 
Receptor for lysophosphatidic acid (LPA) (PubMed9070858, PubMed19306925, PubMed25025571, PubMed26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed19656035, PubMed19733258, PubMed26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed18066075, PubMed19656035, PubMed19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).  
11
  • UniProtKB
GO molecular function 
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
1
  • Ortholog Compara
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • PINC
Lysophosphatidic acid bindingdefinition[GO:0035727]  
1
  • UniProtKB
Lysophosphatidic acid receptor activitydefinition[GO:0070915]  
2
  • UniProtKB
PDZ domain bindingdefinition[GO:0030165] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
1
  • Ortholog Compara
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • UniProtKB
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • Ortholog Curator
Bleb assemblydefinition[GO:0032060] silver  
1
  • Ortholog Compara
Cell chemotaxisdefinition[GO:0060326]  
1
  • UniProtKB
Cellular response to oxygen levelsdefinition[GO:0071453] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Myelinationdefinition[GO:0042552] silver  
1
  • Ortholog Compara
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • Ortholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • PINC
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • UniProtKB
Positive regulation of dendritic spine developmentdefinition[GO:0060999] silver  
1
  • Ortholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • Ortholog Curator
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
1
  • Ortholog Curator
Positive regulation of smooth muscle cell chemotaxisdefinition[GO:0071673] silver  
1
  • Ortholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • Ortholog Curator
Regulation of cell shapedefinition[GO:0008360]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+1902  
Neuroactive ligand-receptor interaction  hsa04080+1902  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
Lysosphingolipid and LPA receptors  R-HSA-419408  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LPAR1
GenomeRNAi: 1902
PRO: PR:Q92633
Chemistry
GuidetoPHARMACOLOGY: 272