LPAR1 - Lysophosphatidic acid receptor 1 - human protein (Function)
 
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LPAR1 »  Lysophosphatidic acid receptor 1  (LPA-1)
 
Protein also known as:  Lysophosphatidic acid receptor Edg-2.
Gene name:  LPAR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
  • IEAOrtholog Compara
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Lysophosphatidic acid receptor activitydefinition[GO:0070915] silver  
  • IEAInterPro 2 GO
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
Phospholipid bindingdefinition[GO:0005543] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • TASPINC
Bleb assemblydefinition[GO:0032060] silver  
  • IEAOrtholog Compara
Cellular response to oxygen levelsdefinition[GO:0071453] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Myelinationdefinition[GO:0042552] silver  
  • IEAOrtholog Compara
Negative regulation of neuron projection developmentdefinition[GO:0010977] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482] silver  
  • IEAOrtholog Compara
Positive regulation of dendritic spine developmentdefinition[GO:0060999] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of Rho protein signal transductiondefinition[GO:0035025] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell chemotaxisdefinition[GO:0071673] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+1902  
Neuroactive ligand-receptor interaction  hsa04080+1902  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LPAR1
GenomeRNAi: 1902
PRO: PR:Q92633
Chemistry
GuidetoPHARMACOLOGY: 272