PIGK - GPI-anchor transamidase - human protein (Function)
 
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PIGK »  GPI-anchor transamidase   [ EC 3.-.-.- ]  (GPI transamidase)
 
Protein also known as:  Phosphatidylinositol-glycan biosynthesis class K protein (PIG-K).
Gene name:  PIGK
Family name: Peptidase C13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 1
GENE REF ISO

Function

 show evidences
Overview 
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAInterPro 2 GO
Contributes to GPI anchor bindingdefinition[GO:0034235]  
1
  • TASUniProtKB
GPI-anchor transamidase activitydefinition[GO:0003923]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein disulfide isomerase activitydefinition[GO:0003756]  
1
  • TASUniProtKB
GO biological process 
Attachment of GPI anchor to proteindefinition[GO:0016255]  
1
  • TASUniProtKB
Protein foldingdefinition[GO:0006457]  
1
  • TASGOC
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis  hsa00563+10026  
Metabolic pathways  hsa01100+10026  
According to Reactome, this protein belongs to the following pathway:
Attachment of GPI anchor to uPAR  REACT_1830  
 

Keywords

Biological process 
GPI-anchor biosynthesis  definition   [KW-0337]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIGK
GenomeRNAi: 10026
PRO: PR:Q92643