SORL1 - Sortilin-related receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SORL1 »  Sortilin-related receptor
 
Protein also known as:  Low-density lipoprotein receptor relative with 11 ligand-binding repeats (LR11).
Gene name:  SORL1
Family name: VPS10-related sortilin » SORL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 113 1
GENE REF ISO

Function

 show evidences
Overview 
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.  
3
  • UniProtKB
GO molecular function 
ADP-ribosylation factor bindingdefinition[GO:0030306]  
1
  • Alzheimers_University_of_Toronto
Beta-amyloid bindingdefinition[GO:0001540]  
2
  • Alzheimers_University_of_Toronto
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • Alzheimers_University_of_Toronto
  • UniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • PINC
GO biological process 
Cell migrationdefinition[GO:0016477] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • UniProtKB KW
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic processdefinition[GO:1902960]  
3
  • Alzheimers_University_of_Toronto
Negative regulation of beta-amyloid formationdefinition[GO:1902430]  
6
  • Alzheimers_University_of_Toronto
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • Ortholog Curator
Negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic processdefinition[GO:1902963]  
2
  • Alzheimers_University_of_Toronto
Negative regulation of neurofibrillary tangle assemblydefinition[GO:1902997]  
1
  • Ortholog Curator
Negative regulation of neurogenesisdefinition[GO:0050768]  
1
  • Ortholog Curator
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • Ortholog Curator
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • Alzheimers_University_of_Toronto
Negative regulation of protein oligomerizationdefinition[GO:0032460]  
1
  • Alzheimers_University_of_Toronto
Negative regulation of tau-protein kinase activitydefinition[GO:1902948]  
1
  • Ortholog Curator
Positive regulation of choline O-acetyltransferase activitydefinition[GO:1902771]  
1
  • Ortholog Curator
Positive regulation of early endosome to recycling endosome transportdefinition[GO:1902955]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of endocytic recyclingdefinition[GO:2001137]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of ER to Golgi vesicle-mediated transportdefinition[GO:1902953]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of protein exit from endoplasmic reticulumdefinition[GO:0070863]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of protein localization to early endosomedefinition[GO:1902966]  
1
  • Alzheimers_University_of_Toronto
Post-Golgi vesicle-mediated transportdefinition[GO:0006892]  
1
  • Alzheimers_University_of_Toronto
Protein maturationdefinition[GO:0051604]  
1
  • Alzheimers_University_of_Toronto
Protein retention in Golgi apparatusdefinition[GO:0045053]  
1
  • Alzheimers_University_of_Toronto
Protein targetingdefinition[GO:0006605]  
2
  • Alzheimers_University_of_Toronto
  • UniProtKB
Protein targeting to Golgidefinition[GO:0000042]  
1
  • Alzheimers_University_of_Toronto
Protein targeting to lysosomedefinition[GO:0006622]  
1
  • Alzheimers_University_of_Toronto
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • PINC
Regulation of smooth muscle cell migrationdefinition[GO:0014910]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • GOC
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Endocytosis  definition   [KW-0254]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6653
PRO: PR:Q92673