CENPI - Centromere protein I - human protein (Function)
 
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Protein
Gene
References

 
CENPI »  Centromere protein I  (CENP-I)
 
Protein also known as:  Follicle-stimulating hormone primary response protein.
Gene name:  CENPI
Family name: Mis6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
GO biological process 
Follicle-stimulating hormone signaling pathwaydefinition[GO:0042699] silver  
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  • Ortholog Compara
Sex differentiationdefinition[GO:0007548]  
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  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Deposition of new CENPA-containing nucleosomes at the centromere  R-HSA-606279  
Mitotic Prometaphase  R-HSA-68877  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
Separation of Sister Chromatids  R-HSA-2467813  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CENPI
GenomeRNAi: 2491
PRO: PR:Q92674