ALG3 - Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase - human protein (Function)
 
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ALG3 »  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase   [ EC 2.4.1.258 ]
 
Protein also known as:  Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase.
Gene name:  ALG3
Family name: Glycosyltransferase 58
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 2
GENE REF ISO

Function

 show evidences
Overview 
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.  
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  • CuratedUniProtKB
GO molecular function 
Alpha-1,3-mannosyltransferase activitydefinition[GO:0000033]  
1
  • IDAUniProtKB
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activitydefinition[GO:0052925]  
  • IEAEC 2 GO
GO biological process 
Mannosylationdefinition[GO:0097502]  
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  • IDAGOC
Protein glycosylationdefinition[GO:0006486]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.258: Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 58  GT58  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+10195  
N-Glycan biosynthesis  hsa00510+10195  
According to Reactome, this protein belongs to the following pathways:
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALG3
GenomeRNAi: 10195
PRO: PR:Q92685