ESR2 - Estrogen receptor beta - human protein (Function)
 
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ESR2 »  Estrogen receptor beta  (ER-beta)
 
Protein also known as:  Nuclear receptor subfamily 3 group A member 2.
Gene name:  ESR2
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 103 9
GENE REF ISO

Function

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Overview 
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed20074560).  
1
  • UniProtKB
GO molecular function 
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Estrogen receptor activitydefinition[GO:0030284]  
1
  • UniProtKB
Estrogen response element bindingdefinition[GO:0034056]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
  • ParkinsonsUK-UCL
Receptor antagonist activitydefinition[GO:0048019]  
1
  • UniProtKB
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingdefinition[GO:0004879]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Steroid bindingdefinition[GO:0005496]  
2
  • UniProtKB
  • Ortholog Curator
Steroid hormone receptor activitydefinition[GO:0003707]  
1
  • PINC
Transcription coactivator activitydefinition[GO:0003713]  
1
  • PINC
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Extracellular negative regulation of signal transductiondefinition[GO:1900116]  
1
  • GOC
Intracellular estrogen receptor signaling pathwaydefinition[GO:0030520]  
1
  • UniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  R-HSA-383280  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Estrogen_receptor_beta
GenomeRNAi: 2100
PRO: PR:Q92731
Chemistry
GuidetoPHARMACOLOGY: 621