RYR2 - Ryanodine receptor 2 - human protein (Function)
 
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RYR2 »  Ryanodine receptor 2  (RyR2)
 
Protein also known as:  Cardiac muscle ryanodine receptor-calcium release channel.
Gene name:  RYR2
Entry whose protein(s) existence is based on evidence at protein level
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1 145 2
GENE REF ISO

Function

 show evidences
Overview 
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family  1.A.3.1.1  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
  • ISSOrtholog Curator
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-induced calcium release activitydefinition[GO:0048763]  
1
  • IDABHF-UCL
Calcium-release channel activitydefinition[GO:0015278]  
1
  • IDABHF-UCL
Calmodulin bindingdefinition[GO:0005516]  
2
  • IPIBHF-UCL
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIBHF-UCL
Intracellular ligand-gated calcium channel activitydefinition[GO:0005218]  
  • ISSOrtholog Curator
Ion channel bindingdefinition[GO:0044325]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein kinase A catalytic subunit bindingdefinition[GO:0034236]  
1
  • IDABHF-UCL
Protein kinase A regulatory subunit bindingdefinition[GO:0034237]  
1
  • IDABHF-UCL
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
Ryanodine-sensitive calcium-release channel activitydefinition[GO:0005219]  
1
  • IDABHF-UCL
Suramin bindingdefinition[GO:0043924]  
1
  • IMPBHF-UCL
GO biological process 
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Calcium ion transportdefinition[GO:0006816]  
1
  • IDABHF-UCL
Calcium ion transport into cytosoldefinition[GO:0060402]  
1
  • IDABHF-UCL
Calcium-mediated signalingdefinition[GO:0019722]  
  • ISSOrtholog Curator
Calcium-mediated signaling using intracellular calcium sourcedefinition[GO:0035584]  
1
  • IDABHF-UCL
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Cardiac muscle hypertrophydefinition[GO:0003300]  
  • ISSOrtholog Curator
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
  • ICGO curators
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Cellular response to caffeinedefinition[GO:0071313]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Cellular response to epinephrine stimulusdefinition[GO:0071872]  
1
  • TASBHF-UCL
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
  • ISSOrtholog Curator
Detection of calcium iondefinition[GO:0005513]  
1
  • IDABHF-UCL
Embryonic heart tube morphogenesisdefinition[GO:0003143]  
  • ISSOrtholog Curator
Establishment of protein localization to endoplasmic reticulumdefinition[GO:0072599]  
1
  • IDABHF-UCL
Left ventricular cardiac muscle tissue morphogenesisdefinition[GO:0003220]  
  • ISSOrtholog Curator
Positive regulation of calcium-transporting ATPase activitydefinition[GO:1901896]  
1
  • IDABHF-UCL
Positive regulation of heart ratedefinition[GO:0010460]  
  • ISSOrtholog Curator
Positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contractiondefinition[GO:0086094]  
  • ISSOrtholog Curator
Positive regulation of sequestering of calcium iondefinition[GO:0051284]  
2
  • IDABHF-UCL
Purkinje myocyte to ventricular cardiac muscle cell signalingdefinition[GO:0086029]  
  • ISSOrtholog Curator
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • IMPBHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
1
  • ICBHF-UCL
  • ISSOrtholog Curator
Regulation of heart ratedefinition[GO:0002027]  
3
  • IMPBHF-UCL
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
2
  • IDABHF-UCL
  • ISSOrtholog Curator
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0014808]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Response to caffeinedefinition[GO:0031000]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666]  
  • ISSOrtholog Curator
Response to redox statedefinition[GO:0051775]  
1
  • IDABHF-UCL
Sarcoplasmic reticulum calcium ion transportdefinition[GO:0070296]  
1
  • TASBHF-UCL
Type B pancreatic cell apoptotic processdefinition[GO:0097050]  
1
  • IMPBHF-UCL
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+6262  
Calcium signaling pathway  hsa04020+6262  
Cardiac muscle contraction  hsa04260+6262  
Dilated cardiomyopathy  hsa05414+6262  
Hypertrophic cardiomyopathy (HCM)  hsa05410+6262  
Pancreatic secretion  hsa04972+6262  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Developmental protein  definition   [KW-0217]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Ryanodine_receptor_2
GenomeRNAi: 6262
PRO: PR:Q92736
Chemistry
GuidetoPHARMACOLOGY: 748