FRZB - Secreted frizzled-related protein 3 - human protein (Function)
 
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FRZB »  Secreted frizzled-related protein 3  (sFRP-3)
 
Protein also known as:  Frizzled-related protein 1.
Gene name:  FRZB
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.  
  • CuratedUniProtKB
GO molecular function 
PDZ domain bindingdefinition[GO:0030165] silver  
  • IBARefGenome
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147]  
  • ISSOrtholog Curator
  • IBARefGenome
GO biological process 
Not  Axonogenesisdefinition[GO:0007409] silver  
  • IRDRefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Cochlea morphogenesisdefinition[GO:0090103] silver  
  • IBARefGenome
Convergent extension involved in organogenesisdefinition[GO:0060029] silver  
  • IEAOrtholog Compara
Epithelium developmentdefinition[GO:0060429] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Mammary gland involutiondefinition[GO:0060056] silver  
  • IBARefGenome
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IDAUniProtKB
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
  • IBARefGenome
Negative regulation of cell developmentdefinition[GO:0010721] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of hepatocyte differentiationdefinition[GO:0070367] silver  
  • IBARefGenome
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Neural crest cell differentiationdefinition[GO:0014033] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IGIMGI
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • IDAMGI
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Somite developmentdefinition[GO:0061053] silver  
  • IEAOrtholog Compara
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2487
PRO: PR:Q92765