CREBBP - CREB-binding protein - human protein (Function)
 
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CREBBP »  CREB-binding protein   [ EC 2.3.1.48 ]
 
Gene name:  CREBBP
Entry whose protein(s) existence is based on evidence at protein level
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1 358 2
GENE REF ISO

Function

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Overview 
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed24939902).  
7
  • UniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
2
  • UniProtKB
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
1
  • BHF-UCL
Damaged DNA bindingdefinition[GO:0003684]  
1
  • UniProtKB
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • UniProtKB
MRF bindingdefinition[GO:0043426]  
1
  • UniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • UniProtKB
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
47
  • IntAct
  • UniProtKB
  • BHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • BHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • BHF-UCL
Signal transducer activitydefinition[GO:0004871]  
2
  • PINC
SMAD bindingdefinition[GO:0046332] silver  
1
  • Ortholog Compara
Contributes to transcription coactivator activitydefinition[GO:0003713]  
6
  • UniProtKB
  • HGNC
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingdefinition[GO:0001228] silver  
1
  • Ortholog Compara
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001078]  
1
  • BHF-UCL
Transcriptional repressor activity, RNA polymerase II transcription factor bindingdefinition[GO:0001191]  
1
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Embryonic digit morphogenesisdefinition[GO:0042733]  
1
  • BHF-UCL
Germ-line stem cell maintenancedefinition[GO:0030718] silver  
1
  • Ortholog Compara
Histone acetylationdefinition[GO:0016573]  
1
  • UniProtKB
Homeostatic processdefinition[GO:0042592]  
1
  • UniProtKB
N-terminal peptidyl-lysine acetylationdefinition[GO:0018076]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
  • Ortholog Curator
Protein acetylationdefinition[GO:0006473]  
1
  • UniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • PINC
Regulation of smoothened signaling pathwaydefinition[GO:0008589]  
1
  • BHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • UniProtKB
  • HGNC
Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
Response to interleukin-1definition[GO:0070555] silver  
1
  • Ortholog Compara
Rhythmic processdefinition[GO:0048511]  
1
  • UniProtKB KW
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+1387  
Cell cycle  hsa04110+1387  
Herpes simplex infection  hsa05168+1387  
HTLV-I infection  hsa05166+1387  
Huntington's disease  hsa05016+1387  
Influenza A  hsa05164+1387  
Jak-STAT signaling pathway  hsa04630+1387  
Long-term potentiation  hsa04720+1387  
Melanogenesis  hsa04916+1387  
Notch signaling pathway  hsa04330+1387  
Pathways in cancer  hsa05200+1387  
Prostate cancer  hsa05215+1387  
Renal cell carcinoma  hsa05211+1387  
TGF-beta signaling pathway  hsa04350+1387  
Tuberculosis  hsa05152+1387  
Wnt signaling pathway  hsa04310+1387  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  R-HSA-2426168  
Attenuation phase  R-HSA-3371568  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  R-HSA-1368108  
CD209 (DC-SIGN) signaling  R-HSA-5621575  
Circadian Clock  R-HSA-400253  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  R-HSA-2894862  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  R-HSA-2644606  
Factors involved in megakaryocyte development and platelet production  R-HSA-983231  
formation of the beta-catenin:TCF transactivating complex  R-HSA-201722  
HATs acetylate histones  R-HSA-3214847  
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production  R-HSA-3134973  
Notch-HLH transcription pathway  R-HSA-350054  
NOTCH1 Intracellular Domain Regulates Transcription  R-HSA-2122947  
PPARA activates gene expression  R-HSA-1989781  
Pre-NOTCH Transcription and Translation  R-HSA-1912408  
Regulation of gene expression by Hypoxia-inducible Factor  R-HSA-1234158  
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)  R-HSA-400206  
RORA activates gene expression  R-HSA-1368082  
TRAF3-dependent IRF activation pathway  R-HSA-918233  
TRAF6 mediated IRF7 activation  R-HSA-933541  
Transcriptional activation of mitochondrial biogenesis  R-HSA-2151201  
Transcriptional regulation of white adipocyte differentiation  R-HSA-381340  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  R-HSA-2032785  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CREB-binding_protein
GenomeRNAi: 1387
PRO: PR:Q92793
Chemistry
GuidetoPHARMACOLOGY: 2734