CREBBP - CREB-binding protein - human protein (Function)
 
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CREBBP »  CREB-binding protein   [ EC 2.3.1.48 ]
 
Gene name:  CREBBP
Entry whose protein(s) existence is based on evidence at protein level
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1 310 2
GENE REF ISO

Function

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Overview 
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.  
5
  • CuratedUniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
1
  • IDAUniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
1
  • IDABHF-UCL
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • IDAUniProtKB
MRF bindingdefinition[GO:0043426]  
1
  • IDAUniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
42
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • TASBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • IDABHF-UCL
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • TASBHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • IPIBHF-UCL
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Signal transducer activitydefinition[GO:0004871]  
2
  • TASPINC
Contributes to transcription coactivator activitydefinition[GO:0003713]  
6
  • IDAUniProtKB
  • IDAHGNC
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Embryonic digit morphogenesisdefinition[GO:0042733]  
1
  • TASBHF-UCL
Germ-line stem cell maintenancedefinition[GO:0030718] silver  
  • IEAOrtholog Compara
Histone acetylationdefinition[GO:0016573]  
1
  • IDAUniProtKB
Homeostatic processdefinition[GO:0042592]  
1
  • NASUniProtKB
N-terminal peptidyl-lysine acetylationdefinition[GO:0018076]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Regulation of smoothened signaling pathwaydefinition[GO:0008589]  
1
  • TASBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • TASUniProtKB
  • IDAHGNC
Response to hypoxiadefinition[GO:0001666]  
1
  • TASUniProtKB
Rhythmic processdefinition[GO:0048511]  
  • IEAUniProtKB KW
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+1387  
Cell cycle  hsa04110+1387  
Herpes simplex infection  hsa05168+1387  
HTLV-I infection  hsa05166+1387  
Huntington's disease  hsa05016+1387  
Influenza A  hsa05164+1387  
Jak-STAT signaling pathway  hsa04630+1387  
Long-term potentiation  hsa04720+1387  
Melanogenesis  hsa04916+1387  
Notch signaling pathway  hsa04330+1387  
Pathways in cancer  hsa05200+1387  
Prostate cancer  hsa05215+1387  
Renal cell carcinoma  hsa05211+1387  
TGF-beta signaling pathway  hsa04350+1387  
Tuberculosis  hsa05152+1387  
Wnt signaling pathway  hsa04310+1387  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
Attenuation phase  REACT_200624  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Circadian Clock  REACT_24941  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
HATs acetylate histones  REACT_172610  
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production  REACT_163743  
Notch-HLH transcription pathway  REACT_14835  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
PPARA activates gene expression  REACT_116145  
Pre-NOTCH Transcription and Translation  REACT_118568  
Regulation of gene expression by Hypoxia-inducible Factor  REACT_121092  
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)  REACT_19241  
REV-ERBA represses gene expression  REACT_118789  
RORA activates circadian gene expression  REACT_118659  
TRAF3-dependent IRF activation pathway  REACT_25026  
TRAF6 mediated IRF7 activation  REACT_24938  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CREB-binding_protein
GenomeRNAi: 1387
PRO: PR:Q92793
Chemistry
GuidetoPHARMACOLOGY: 2734