DLG3 - Disks large homolog 3 - human protein (Function)
 
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Protein
Gene
References

 
DLG3 »  Disks large homolog 3
 
Protein also known as:  Synapse-associated protein 102 (SAP102).
Gene name:  DLG3
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

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Overview 
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.  
1
  • UniProtKB
GO molecular function 
Guanylate kinase activitydefinition[GO:0004385]  
1
  • RefGenome
Ionotropic glutamate receptor bindingdefinition[GO:0035255]  
1
  • RefGenome
Kinase bindingdefinition[GO:0019900]  
1
  • MGI
PDZ domain bindingdefinition[GO:0030165] silver  
1
  • Ortholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein phosphatase bindingdefinition[GO:0019903] silver  
1
  • Ortholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
1
  • Ortholog Compara
GO biological process 
Establishment of planar polaritydefinition[GO:0001736] silver  
1
  • Ortholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197]  
1
  • RefGenome
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • RefGenome
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • RefGenome
Receptor clusteringdefinition[GO:0043113]  
1
  • RefGenome
Receptor localization to synapsedefinition[GO:0097120]  
1
  • RefGenome
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of Ca-permeable Kainate Receptor  REACT_21346  
NrCAM interactions  REACT_22329  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1741
PRO: PR:Q92796