DLG3 - Disks large homolog 3 - human protein (Function)
 
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Protein
Gene
References

 
DLG3 »  Disks large homolog 3
 
Protein also known as:  Synapse-associated protein 102 (SAP102).
Gene name:  DLG3
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 3
GENE REF ISO

Function

 show evidences
Overview 
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.  
  • CuratedUniProtKB
GO molecular function 
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
  • IEAOrtholog Compara
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
  • IEAOrtholog Compara
GO biological process 
Establishment of planar polaritydefinition[GO:0001736] silver  
  • IEAOrtholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • NASUniProtKB
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of Ca-permeable Kainate Receptor  REACT_21346  
NrCAM interactions  REACT_22329  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1741
PRO: PR:Q92796